An ingredient with proven effectiveness on oily and acne-prone skin.
A key plant of European phytotherapy formerly known for its numerous culinary or therapeutic uses, Laboratoires Dermatologues Avène are the first to select Milk Thistle for its powerful and patented activities to reduce excess sebum and imperfections (blemishes, blackheads).
This research has led to a new active ingredient with patented properties: ComedoclastinTM.
Liquid extraction
Active ingredient with patented* properties
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ComedoclastinTM, a new ingredient with patented properties derived from Pierre Fabre's expertise

After 8 years of research and development to extract the most active component of the plant, Laboratoires Dermatologues Avène have produced ComedoclastinTM from the seeds of Milk Thistle (Sylibum marianium L.). Pierre Fabre Botanical Expertise has obtained the active molecules and stabilised them to obtain a unique concentrate, an oil rich in active ingredients extracted from cold-pressed seeds in our ISO9100 certified factory in Gaillac, which guarantees traceability, safety and control of the manufacturing process.

Predominantly grown in France in a short supply chain within a non-destructive industry, milk thistle extract meets the four founding pillars of the Pierre Fabre Botanical Expertise approach, a certified responsible development approach that consists of innovating through nature: to help fight against the depletion of plant resources and contribute to their preservation, while guaranteeing the extreme quality of active plant ingredients, the security of supplies and respecting our partners* *

And in a circular economy context, the residual oil of milk thistle obtained after extraction is also recovered.

Unique action on blemishes. 

The formation of blemishes is a multi-step process. Before the pimple is visible on the surface of the skin, the sebaceous follicle that contains it will undergo several changes; some will evolve into a stage called microcomedones, which are the precursors of any future blemishes. The cells on the wall then multiply, contributing to the formation of a plug that will block the flow of sebum, which would have also become more compact.

By focusing on this key stage of acne, Avene Dermatological Laboratories have discovered that in order to act effectively and reduce pimples permanently, it is important to take effective action in both the visible and invisible stages. In order to prevent visible blemishes, ComedoclastinTM takes several measures at once:

  • A mattifying action, where it acts by absorbing excess sebum
  • A comedolytic action where it limits the proliferation of cells that thicken the sebaceous follicle channel. 

Phew, due to that, the micro blackheads are unclogged once again. 

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ComedoclastinTM is an effective part of our Cleanance Comedomed skin care range.

We have applied the effectiveness of our star ingredient ComedoclastinTMto our entireCleanance Comedomedskin care range to care for oily or blemish-prone skin in two ways:

  • In a hyper-concentrated form, with a 25% concentration of Cleanance Comedomed Anti-Blemish Concentrate, a product that reduces the appearance of blemishes and blackheads while limiting their recurrence to leave your skin looking clear.
  • Combined with other ingredients across other products in the range such as Cleanance Gel, a mattifying gel cleanser that removes oil and impurities for perfectly cleansed and matte skin.
In the same range



Cleanance Comedomed

Cleanance Comedomed

Reduces excess sebum - Reduces imperfections - Tightens pores

Cleanance Comedomed Localised Drying Emulsion

Cleanance Comedomed Localised Drying...

Reduces residual marks - Dries out imperfections

Cleanance Cleansing Gel

Cleanance Cleansing Gel

Mattifies - Cleanses - Purifies

Cleanance Micellar Water

Cleanance Micellar Water

Removes make-up - Mattifies - Cleanses

Cleanance Comedomed Anti-Blemish Concentrate: proven effectiveness

  • Skin in clearer after 7 days1
  • -90% recurrence2
  • +54% confidence restored2

1Clinical study, significant reduction in blemishes observed under dermatological control on 51 subjects for 7 days. Use of Cleanance Comedomed twice a day for 56 days.
2Comparative study conducted on 36 subjects under dermatological control for 56 days. One group no application (N=18), one group using Cleanance Comedomed (N=18), twice a day.


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