Cleanance Comedomed

Reduces imperfections - Reduces excess sebum - Tightens pores

Cleanance Comedomed, an innovation from Laboratoires Eau Thermale Avène, fights blemishes and prevents them from reappearing, with clinically proven effectiveness from seven days*. High tolerance for blemish-prone skin.

  • Fast action
  • Anti-recurrence***
  • High tolerance
  • Fragrance-free

Effectiveness demonstrated within 7 days*.

Pump bottle

Usable by Pregnant women - Young mothers - Teenagers - Adults

Age From 12 year(s)

Skin type Acne-prone skin

Need Anti-imperfections - Anti recurrence

Made in France

Environmental impact



Biodegradable formula*
Formulated to limit the impact on the aquatic environment***
*According to a OECD 301 test or biodegradability index method
*** According to a OECD 301 test and CLP classification of the formula



Mostly recyclable packaging



Formulated with one or more raw materials from the circular economy
Manufactured and packaged in an environmentally certified facility****
Cold-made formula without any heating
****According to ISO 14001 and/or 50001

Societal impact


Product manufactured and packaged in a factory with high social sustainability standards
Avene is a brand of the Pierre Fabre Group, certified at the highest Exemplary level of AFNOR Certification’s Committed to CSR and Responsibility Europe labels, thus consolidating a long-standing commitment to contributing to sustainable ... development.
Does not contain animal raw materials Our commitments


Helping you get rid of blemishes once and for all

Playing YouTube videos requires the use of cookies in order to offer you targeted advertising based on your browsing For more information, please visit YouTube's « cookie » policy.

You have rejected Youtube's cookies and therefore you cannot view the video.

You can change your choices by clicking on « Cookie Settings » and accept Youtube's cookies to enable the video.

You can change this setting and withdraw your consent at any time.

Frequency of use

2 times a day

Tips for use

Dispense 1 dose of Cleanance Comedomed on your fingertips.
• Start by dabbing it onto the T-zone and the cheeks.
• Use circular motions to boost penetration.
• Finish by smoothing on the cheeks and lower face.
Reapply morning and evening.

An expert tip

The 2 essential steps to take care of your oily, acne-prone skin!
Our one piece of advice:
• Rigorously yet gently remove make-up and cleanse the face, both morning and evening!
• Also apply an anti-blemish product morning and evening.

Clinical results

Effective for every oily,acne-prone skin type

7 daysreduces spots within 7 days¹
90%prevents recurrence for 90%²
45%reduced imperfections by -45% as of 2 months³, significant result versus control group

¹Tolerance and efficacy study under dermatological control on 51 subjects, use of Cleanance Comedomed twice a day for 56 days.
²International observational clinical study, 90% of patients without acne relapse at T6 months, (according to the definition of relapse in the protocol GEA≥3 requiring the introduction of an oral or local drug treatment), 48 subjects, 2 applications per day of Cleanance Comedomed alone for 6 months.
³36 subjects with slight to moderate imperfections. Comparative clinical study (group treated twice/day N=18), control group (N=18) for 56 days.


*Tolerance and efficacy study under dermatological control on 51 subjects, use of Cleanance Comedomed twice a day for 56 days.
** Patent registered.
***International clinical observational study, 90% of individuals without blemish relapse at T6 months, (according to the definition of relapse in the GEA protocol ≥3 requiring the introduction of a drug treatment – oral or local), 48 subjects, two applications per day of Cleanance Comedomed for six months.

Display sources Hide sources
Ingredients Ingredients

A combination of innovative active ingredients selected for their effectiveness on sensitive oily,acne-prone skin.


The consumer is advised to systematically check the composition of the product before purchasing it.

Avene thermal water


Thanks to a unique mineral and biological characteristic, it has soothing, repairing and rebalancing properties.



Plant-based active ingredient with patented properties from Pierre Fabre Research. Milk thistle extract acts on epithelial cells reducing the formation of micro-comedones and preventing new spots.


Any concerns or questions? Our experts are here for you.

Rest assured, Cleanance Comedomed does not contain any.

The smell is linked to the active ingredient Comedoclastin™ (milk thistle extract), which is present in the product at a dosage of 25%. This odour evaporates quickly and does not interfere with the tolerance of the product and does not present any risk to the skin. It has been proven that skin tolerates Cleanance Comedomed extremely well.

Yes, the start of an active treatment (whether a drug or dermo-cosmetic) can act as a trigger for a breakout. Under its effect, a large number of spots, previously dormant under the skin, emerge at the same time. This causes the phenomenon of a "flare-up" (an explosion or exacerbation of pimples). Treatment should be continued in all cases, because the next phase will allow for the rapid exhaustion of the "embryo stock” of spots.This will help to keep blemishes to a minimum.
In case of discomfort, use can be reduced to once a day.

love salmon-2x


An active water, a source of innovation

Find out more ->

Back to top