At the heart of Avène thermal spring water is a unique and multi-competent active ingredient, a source of softening and soothing for dry and itchy skin...
I-modulia® is the first multi-competent biotechnological active ingredient derived from Avène thermal spring water. It acts directly on the factors involved in dry skin.
An anti-irritant, this unique post-biotic active ingredient reduces itching caused by dryness.
Origin: biotechnological
Source: France
Patent: Patented* active ingredient
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I-modulia®: back to the source 

Avène thermal spring water is a treasure trove... But what exactly is the secret behind its
calming properties?

Beyond being rich in minerals, it draws its effectiveness from its biological history.

Our researchers have identified an original microflora that lives only in the very deep and pure waters of Avène: Aquaphilus dolomiae. It is from this specific microorganism that we have succeeded in extracting I-modulia®, the first biotechnological active ingredient derived from Avène thermal spring water

The result of more than 12 years of multidisciplinary research, this multi-competent active ingredient acts directly on the itching of dry skin.

After years of research, we have developed a biological active ingredient with exceptional properties. Acting directly on itching caused by dryness, it has the unique ability to soften and soothe dry to very dry skin.

NATHALIE CASTEX-RIZZI, PHDPharmacology Manager, Scientific Evaluation Department

An exceptional and multi-competent active ingredient!

I-modulia® is the anti-itching active ingredient par excellence to relieve dry skin..

I-modulia is a natural active ingredient obtained from Aquaphilus dolomiae fractions.

As an anti-irritant, it has a direct action on dryness, itching, and the appearance of redness.


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Put a STOP to dry, itchy skin

Dry or very dry is almost always synonymous with itching and great discomfort.

XeraCalm A.D. high performance skin care products have been specially developed to act on dryness and itching and to restore the skin barrier. Formulated with ingredients chosen for their efficacy, they are ideal for the skin of infants, children and adults.

By now you know: I-modulia®, our first postbiotic active ingredient extracted from Avène thermal spring water, is the key ingredient in these ultra-softening and soothing skin care products!

The result? The skin is instantly and lastingly moisturised and protected. The whole family can enjoy the peace of mind that comes with 5 days of scratch-free effectiveness (1).

Is it really that itchy? Claim your right to soft and soothed skin!

Is it really that itchy? Claim your right to soft and soothed skin!

Discover our ultra-innovative hygiene and moisturising products, designed for dry skin. Everything for your anti-itching routine!



The ingredients in our products are carefully selected for their effectiveness.


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First post-biotic restoring active ingredient from Avène Thermal Spring Water. It provides the optimal environment for the skin's own natural renewal.

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Avène Thermal Spring Water

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Thanks to its unique mineral and organic signature, it has softening soothing, and restoring properties.

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Patented post-biotic active ingredient* from Avène Thermal Spring Water. Instant ultra-calming effect on all skin sensations.


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*Patent pending

(1) Average time for itching to disappear. Phase IV study on 1,711 patients (France, French overseas territories, Italy). For 75% of patients, use of XeraCalm A.D alone once or twice a day for 7 days in the pruritic xerosis indication.

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